Abstract
An adaptive optics (AO) system was used to investigate the effect of long-term neural adaptation to the habitual optical profile on neural contrast sensitivity in pseudophakic eyes after the correction of all aberrations, defocus, and astigmatism. Pseudophakic eyes were assessed at 4 and 8 months postoperatively for changes in visual performance. Visual benefit was observed in all eyes at all spatial frequencies after AO correction. The average visual benefit across spatial frequencies was higher in the pseudophakic group (3.31) at 4 months postoperatively compared to the normal group (2.41). The average contrast sensitivity after AO correction in the pseudophakic group improved by a factor of 1.73 between 4 and 8 months postoperatively. Contrast sensitivity in pseudophakic eyes was poorer, which could be attributed to long-term adaptation to the habitual optical profiles before the cataract surgery, in conjunction with age-related vision loss. Improved visual performance in pseudophakic eyes suggests that the aged neural system can be re-adapted for altered ocular optics.