Abstract
1 Secrection of amylase from rat pancreas stimualted by urecholine was studied in relation to its inhibition by atropine and 3-quinuclidinyl benzilate (QNB). 2 Urecholine-induced secretion was completely abolished by atropine at 10(-6)M and QNB at 10(-8)M. Significant inhibition could be detected at 10(-8)M atropine and 10(-10)M QNB. 3 The secretory response to pancreozymin was not blocked either by atropine or QNB. 4 The inhibitory effect of QNB remained for at least 90 min after its removal from the incubation medium. 5 It is concluded that QNB is 10 times more potent than atropine in inhibiting pancreatic amylase secretion induced by urecholine.