Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression

肿瘤细胞驱动的细胞外基质重塑在转移进展过程中推动细胞趋触性

阅读：5

作者：Madeleine J Oudin, Oliver Jonas, Tatsiana Kosciuk, Liliane C Broye, Bruna C Guido, Jeff Wyckoff, Daisy Riquelme, John M Lamar, Sreeja B Asokan, Charlie Whittaker, Duanduan Ma, Robert Langer, Michael J Cima, Kari B Wisinski, Richard O Hynes, Douglas A Lauffenburger, Patricia J Keely, James E Bear, Fr

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2016

起止号：

2016 May;6(5):516-31.

doi：

10.1158/2159-8290.CD-15-1183

方法学：

研究方向：

肿瘤

细胞类型：

肿瘤细胞

Significance

Here, we provide new insight into how tumor cell:ECM interactions generate signals and structures that promote directed tumor cell migration, a critical component of metastasis. Our results identify a tumor cell-intrinsic mechanism driven by the actin regulatory protein MENA that promotes ECM remodeling and haptotaxis along FN gradients. Cancer Discov; 6(5); 516-31. ©2016 AACR.See related commentary by Santiago-Medina and Yang, p. 474This article is highlighted in the In This Issue feature, p. 461.

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