Sequence and antigenic variability of the Helicobacter mustelae surface ring protein Hsr

幽门螺杆菌表面环状蛋白Hsr的序列和抗原变异性

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Abstract

We have identified an array of more than 500 repetitive sequences flanking the hsr gene, which encodes the major surface protein of the ferret pathogen Helicobacter mustelae. The repeats show identity exclusively to the amino-terminal half of Hsr. Analysis of Hsr from three strains indicated variability of exposed epitopes. Characterization of an hsr mutant showed that Hsr is not an adhesin.

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