Promiscuous Recognition of a Trypanosoma cruzi CD8+ T Cell Epitope among HLA-A2, HLA-A24 and HLA-A1 Supertypes in Chagasic Patients

恰加斯病患者中 HLA-A2、HLA-A24 和 HLA-A1 超型对克氏锥虫 CD8+ T 细胞表位的混杂识别

阅读：11

作者：Paola Lasso, Lina Beltrán, Fanny Guzmán, Fernando Rosas, M Carmen Thomas, Manuel Carlos López, John Mario González, Adriana Cuéllar, Concepción J Puerta

期刊：

PLoS One

影响因子：

2.900

时间：

2016

起止号：

2016 Mar 14;11(3):e0150996.

doi：

10.1371/journal.pone.0150996

研究方向：

细胞生物学

细胞类型：

T细胞

Background

TcTLE is a nonamer peptide from Trypanosoma cruzi KMP-11 protein that is conserved among different parasite strains and that is presented by different HLA-A molecules from the A2 supertype. Because peptides presented by several major histocompatibility complex (MHC) supertypes are potential targets for immunotherapy, the

Significance

These results show that TcTLE is a promiscuous peptide that is presented by the A24 and A1 supertypes, in addition to the A2 supertype, suggesting its potential as a target for immunotherapy.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用；引用内容仅为补充信息，不代表本站立场。

2、若认为本页面引用内容涉及侵权，请及时与本站联系，我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容，需注明“来源：[生知库]”并获得授权；使用引用内容的，需自行联系原作者获得许可。

4、投稿及合作请联系：info@biocloudy.com。