Nucleolar Localization of the RNA Helicase DDX21 Predicts Survival Outcomes in Gynecologic Cancers
RNA 解旋酶 DDX21 的核仁定位可预测妇科癌症的生存结果
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作者：Marwa W Aljardali, Kevin M Kremer, Jessica E Parker, Elaine Fleming, Hao Chen, Jayanthi S Lea, W Lee Kraus, Cristel V Camacho
Significance
Currently, there are no reliable biomarkers for response to PARPi outside of homologous recombination deficiency. Herein we present a unique potential biomarker, with clear functional understanding of the molecular mechanism by which DDX21 nucleolar localization can predict response to PARPi.
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