Synthesis, Characterization and Cytotoxicity of Novel Multifunctional Fe₃O₄@SiO₂@GdVO₄:Dy(3+) Core-Shell Nanocomposite as a Drug Carrier

新型多功能Fe₃O₄@SiO₂@GdVO₄:Dy(3+)核壳纳米复合材料的合成、表征及细胞毒性研究及其作为药物载体的应用

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Abstract

In this study, multifunctional Fe₃O₄@SiO₂@GdVO₄:Dy(3+) nanocomposites were successfully synthesized via a two-step method. Their structure, luminescence and magnetic properties were characterized by X-ray diffraction (XRD), scanning electronic microscope (SEM), transmission electron microscopy (TEM), photoluminescence (PL) spectra and vibrating sample magnetometer (VSM). The results indicated that the as-prepared multifunctional composites displayed a well-defined core-shell structure. The composites show spherical morphology with a size distribution of around 360 nm. Additionally, the composites exhibit high saturation magnetization (20.40 emu/g) and excellent luminescence properties. The inner Fe₃O₄ cores and the outer GdVO₄:Dy(3+) layers endow the composites with good responsive magnetic properties and strong fluorescent properties, which endow the nanoparticles with great potential applications in drug delivery, magnetic resonance imaging, and marking and separating of cells in vitro.

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