Abstract
Efficient exchange of nutrients and wastes required for cell proliferation and differentiation plays a pivotal role in improving the service life of porous implants. In this study, mass transport properties for porous implant with different unit cells were evaluated and predicted when the porosities are kept the same. To this end, three typical unit cells (diamond (DO), rhombic dodecahedron (RD), and octet truss (OT)) were selected, in which DO displayed diagonal-symmetrical shape, while RD and OT share midline-symmetrical structure. Then, single unit cells were designed quantitatively, and its shape parameters were measured and calculated. Moreover, corresponding porous scaffolds with same outline size were created, respectively. Furthermore, using computational fluid dynamics (CFD) methodology, flow performances with Dulbecco's Modified Eagle's Medium (DMEM) in vitro were simulated for three different porous implants, and flow trajectory, velocity, and wall shear stress which could reflect the properties of mass transfer and tissue regeneration were compared and predicted numerically. Results demonstrated that different unit cell could directly lead to different mass transport properties for porous implant, in spite of same porosity, scaffold size, and service environment. Additionally, by the results, DO displayed greater tortuosity, more appropriate areas, and smoother shear stress distribution than RD and OT, which would provide better surroundings for implant fixation and tissue regeneration. However, RD and OT showed better mass transport properties because of bigger maximum velocity (5.177 mm/s, 4.381 mm/s) than DO (3.941 mm/s). This study would provide great helps for unit cell selection and biological performance optimization for 3D printed bone implants.