Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum

OBJECTIVES: To advance our biological understanding of pediatric septic shock, we measured the genome-level expression profiles of critically ill children representing the systemic inflammatory response syndrome (SIRS), sepsis, and septic shock spectrum. DESIGN: Prospective observational study involving microarray-based bioinformatics. SETTING: Multiple pediatric intensive care units in the United States. PATIENTS: Children