Abstract
Plants face numerous environmental stresses that hinder their growth and productivity, including biotic agents, such as herbivores and parasitic microorganisms, as well as abiotic factors, such as cold, drought, salinity, and high temperature. To counter these challenges, plants have developed a range of defense strategies. Among these, plant antimicrobial proteins and peptides (APPs) have emerged as a promising solution. Due to their broad-spectrum activity, structural stability, and diverse mechanisms of action, APPs serve as powerful tools to complement and enhance conventional agricultural methods, significantly boosting plant defense and productivity. This review focuses on different studies on APPs, emphasizing their crucial role in combating plant pathogens and enhancing plant resilience against both biotic and abiotic stresses. Beginning with in vitro studies, we explore how APPs combat various plant pathogens. We then delve into the defense mechanisms triggered by APPs against biotic stress, showcasing their effectiveness against bacterial and fungal diseases. Additionally, we highlight the role of APPs in mitigating the abiotic challenges associated with climatic change. Finally, we discuss the current applications of APPs in agriculture, emphasizing their potential for sustainable agricultural practices and the need for future research in this area.