Abstract
Autoimmune progesterone dermatitis is considered a rare cyclical autoimmune reaction to endogenous progesterone in fertile females that is characterized by skin lesions ranging from mild urticaria to anaphylaxis. A 30-year-old woman who had an intrauterine device placed, presented to her family medicine clinic with erythema and some edematous lesions, and pruritus. The skin biopsy showed perivascular infiltrate with neutrophils and was diagnosed as autoimmune progesterone dermatitis. Treatment included intrauterine device removal and treatment with tamoxifen. This is the first documented case of autoimmune progesterone dermatitis in occupied Palestine.