LncRNA HOTAIR sponges miR-301a-3p to promote glioblastoma proliferation and invasion through upregulating FOSL1

LncRNA HOTAIR 通过上调 FOSL1 吸收 miR-301a-3p 来促进胶质母细胞瘤增殖和侵袭

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作者:Shanchun Guo, Pendelton King, Emily Liang, Alyssa A Guo, Mingli Liu

Significance

Our study elucidated the role of TRPM7-mediated HOTAIR as a miRNA sponge to target downstream FOSL1 oncogene and therefore consequently contribute to gliomagenesis, which shed new light on TRPM7/lncRNA-directed diagnostic and therapeutic approach in glioma.

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