Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

基因组拷贝数决定了细胞对 CRISPR/Cas9 靶向的基因独立反应

阅读：6

作者：Andrew J Aguirre, Robin M Meyers, Barbara A Weir, Francisca Vazquez, Cheng-Zhong Zhang, Uri Ben-David, April Cook, Gavin Ha, William F Harrington, Mihir B Doshi, Maria Kost-Alimova, Stanley Gill, Han Xu, Levi D Ali, Guozhi Jiang, Sasha Pantel, Yenarae Lee, Amy Goodale, Andrew D Cherniack, Coyin Oh,

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2016

起止号：

2016 Aug;6(8):914-29.

doi：

10.1158/2159-8290.CD-16-0154

研究方向：

细胞生物学

细胞类型：

其它细胞

Significance

We found that the number of CRISPR/Cas9-induced DNA breaks dictates a gene-independent antiproliferative response in cells. These observations have practical implications for using CRISPR/Cas9 to interrogate cancer gene function and illustrate that cancer cells are highly sensitive to site-specific DNA damage, which may provide a path to novel therapeutic strategies. Cancer Discov; 6(8); 914-29. ©2016 AACR.See related commentary by Sheel and Xue, p. 824See related article by Munoz et al., p. 900This article is highlighted in the In This Issue feature, p. 803.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用；引用内容仅为补充信息，不代表本站立场。

2、若认为本页面引用内容涉及侵权，请及时与本站联系，我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容，需注明“来源：[生知库]”并获得授权；使用引用内容的，需自行联系原作者获得许可。

4、投稿及合作请联系：info@biocloudy.com。