Abstract
To evaluate the correlation between plasma fibrinogen levels and acute myocardial infarction (AMI) in the Chinese Han population. A total of 1522 patients with incident AMI and 6125 controls were recruited between January 1, 2010, and December 31, 2013. The relationship between fibrinogen levels and incident AMI was evaluated using multivariable-adjusted logistic regression, and the possible interaction effects between fibrinogen and other risk factors on incident AMI were investigated. When modeled as a continuous variable, a 1 g/L increase in fibrinogen level was associated with a 91% increase in the risk of AMI [odds ratio (OR):1.91; 95% confidence interval (CI):1.63-2.23 in women, 1.86:1.70-2.03 in men, and 1.85:1.72-2.00 in total]. Compared to 1st quartile of fibrinogen levels, the adjusted ORs for first incident AMI was 3.25 (2.67-3.96) for the fourth quartile, 1.61 (1.30-1.99) for the third one, 1.18 (0.96-1.46) for the second one (P < 0.001). High fibrinogen levels are associated with an increased risk of incident AMI in the Chinese Han population, and fibrinogen could be an important biomarker for AMI risk assessment.