Characterization of the transient middle cerebral artery occlusion model of ischemic stroke in a HuR transgenic mouse line

HuR 转基因小鼠中短暂性大脑中动脉闭塞缺血性中风模型的表征

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作者:A Ardelt, R Carpenter, I Iwuchukwu, A Zhang, W Lin, E Kosciuczuk, C Hinkson, T Rebeiz, S Reitz, P King

Abstract

This set of experiments characterizes a model of transient cerebral ischemic stroke in a transgenic (Tg) mouse line in which the glial fibrillary acidic protein (GFAP) promoter is utilized to drive expression of a human RNA-binding protein, HuR. Additionally, the effect of cerebral ischemia on the expression of endogenous Hu proteins is presented.

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