Abstract
Infusions of cholinomimetics, either systemically in normal humans, or directly into the brain stem of unanesthetized cats and rats, readily induce rapid eye-movement (REM) sleep. In anesthetized cats and rats, infusions of cholinomimetics have been shown to produce both increases and decreases in arterial blood pressure. We determined the relation of these blood pressure changes to REM sleep, by examining both blood pressure and sleep states after injecting carbachol at midbrain, pontine, and medullary sites in unanesthetized cats. In the pons, carbachol infusions produced an early decrease in blood pressure followed by a sustained hypertensive effect. The early blood pressure decrease was associated with the occurrence of REM sleep; however, higher values were associated with later REM sleep episodes. In other brain stem sites carbachol did not produce REM sleep or its associated reductions in blood pressure. Instead it produced a hypertensive response that increased throughout the 1-h observation period. We hypothesize that pontine muscarinic mechanisms trigger REM sleep and a REM sleep-associated decrease in blood pressure. Thereafter, nicotinic receptors mediating the blood pressure increase override the muscarinic-induced decrease.