Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins

脂肪细胞衍生的脂质通过 FATP 蛋白介导黑色素瘤进展

阅读：11

作者：Maomao Zhang, Julie S Di Martino, Robert L Bowman, Nathaniel R Campbell, Sanjeethan C Baksh, Theresa Simon-Vermot, Isabella S Kim, Pearce Haldeman, Chandrani Mondal, Vladimir Yong-Gonzales, Mohsen Abu-Akeel, Taha Merghoub, Drew R Jones, Xiphias Ge Zhu, Arshi Arora, Charlotte E Ariyan, Kivanç Birsoy,

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2018

起止号：

2018 Aug;8(8):1006-1025.

doi：

10.1158/2159-8290.CD-17-1371

研究方向：

信号转导、肿瘤

疾病类型：

黑色素瘤

细胞类型：

其它细胞

Significance

We demonstrate that stromal adipocytes are donors of lipids that mediate melanoma progression. Adipocyte-derived lipids are taken up by FATP proteins that are aberrantly expressed in melanoma. Inhibition of FATPs decreases melanoma lipid uptake, invasion, and growth. We provide a mechanism for how stromal adipocytes drive tumor progression and demonstrate a novel microenvironmental therapeutic target. Cancer Discov; 8(8); 1006-25. ©2018 AACR.This article is highlighted in the In This Issue feature, p. 899.

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