Abstract
Calibrated blood oxygenation level dependent (BOLD) imaging, a technique used to measure changes in cerebral O(2) metabolism, depends on an accurate model of how the BOLD signal is affected by the mismatch between changes in cerebral blood flow (CBF) and cerebral metabolic rate of O(2) (CMRO(2)). However, other factors such as the cerebral blood volume (CBV) distribution at rest and with activation also affect the BOLD signal. The Davis model originally proposed for calibrated BOLD studies (Davis et al., 1998) is widely used because of its simplicity, but it assumes CBV changes are uniformly distributed across vascular compartments, neglects intravascular signal changes, and ignores blood-tissue signal exchange effects as CBV increases and supplants tissue volume. More recent studies suggest that venous CBV changes are smaller than arterial changes, and that intravascular signal changes and CBV exchange effects can bias estimated CMRO(2). In this paper, recent experimental results for the relationship between deoxyhemoglobin and BOLD signal changes are integrated in order to simulate the BOLD signal in detail by expanding a previous model to include a tissue compartment and three blood compartments rather than only the venous blood compartment. The simulated data were then used to test the accuracy of the Davis model of calibrated BOLD, demonstrating that the errors in estimated CMRO(2) responses across the typical CBF-CMRO(2) coupling range are modest despite the simplicity of the assumptions underlying the original derivation of the model. Nevertheless, the accuracy of the model can be improved by abandoning the original physical meaning of the two parameters α and β and treating them as adjustable parameters that capture several physical effects. For a 3Tesla field and a dominant arterial volume change with activation, the accuracy of the Davis model is improved with new values of α=0.14 and β=0.91.