Abstract
Since young adulthood is a vulnerable period for adverse mental health experiences and high-risk substance use, it is critical to understand the impact of the COVID-19 pandemic on young adult mental health and substance use behaviors. Therefore, we determined whether the relationship between COVID-related stressors and using substances to cope with COVID-related social distancing and isolation was moderated by depression and anxiety among young adults. Data were from the Monitoring the Future (MTF) Vaping Supplement (total N = 1244). Logistic regressions assessed the relations between COVID-related stressors, depression, anxiety, demographic characteristics, and interactions between depression/anxiety and COVID-related stressors with vaping more, drinking more, and using marijuana to cope with COVID-related social distancing and isolation. Greater COVID-related stress due to social distancing was associated with vaping more to cope among those with more depression symptoms and drinking more to cope among those with more symptoms of anxiety. Similarly, COVID-related economic hardships were associated with using marijuana to cope among those with more symptoms of depression. However, feeling less COVID-related isolation and social distancing stress was linked to vaping and drinking more to cope, respectively, among those with more symptoms of depression. These findings suggest that the most vulnerable young adults are seeking substances to cope with the pandemic, while potentially experiencing co-occurring depression and anxiety along with COVID-related stressors. Therefore, intervention programs to support young adults who are struggling with their mental health in the aftermath of the pandemic as they transition into adulthood are critical.