NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors

基于核磁共振光谱的血小板代谢组学分析脑肿瘤

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作者:Shivanand Pudakalakatti, Alessandra Audia, Anirudh Mukhopadhyay, José S Enriquez, Dontrey Bourgeois, Nabihah Tayob, Niki M Zacharias, Steven W Millward, Daniel Carson, Mary C Farach-Carson, Frederick F Lang, Amy B Heimberger, Krishna P Bhat, Pratip K Bhattacharya

Abstract

"Tumor-educated platelets" have recently generated substantial interest for the diagnosis of cancer. We hypothesized that tumor educated platelets from patients with brain tumors will reflect altered metabolism compared to platelets from healthy volunteers. Here, in a pilot study, we have employed nuclear magnetic resonance (NMR) spectroscopy in platelets from brain tumor patients to demonstrate altered metabolism compared to the platelets obtained from healthy volunteers.

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