Abstract
We highlight a recent paper which documents the important role that Ca(2+) release through type-1 Inositol 1,4,5-trisphosphate receptor (IP(3)R1) plays in the acute regulation by glucagon of gluconeogenesis in hepatocytes. The specificity is likely the result of discrete localization close to mitochondria and PKA-dependent phosphorylation of IP(3)R1 which enhances Ca(2+) release.