MYC is Sufficient to Generate Mid-Life High-Grade Serous Ovarian and Uterine Serous Carcinomas in a p53-R270H Mouse Model

MYC 足以在 p53-R270H 小鼠模型中产生中年高级别浆液性卵巢癌和子宫浆液性癌

阅读：10

作者：Alexandra Blackman #, Amy C Rees #, Robert R Bowers #, Christian M Jones #, Silvia G Vaena, Madison A Clark, Shelby Carter, Evan D Villamor, Della Evans, Anthony J Emanuel, George Fullbright, Matthew S O'Malley, Richard L Carpenter, David T Long, Laura S Spruill, Martin J Romeo, Brian C Orr, Kristi

期刊：

Cancer Research Communications

影响因子：

2.000

时间：

2024

起止号：

2024 Sep 1;4(9):2525-2538.

doi：

10.1158/2767-9764.CRC-24-0144

种属：

Human

研究方向：

肿瘤

疾病类型：

卵巢癌

Significance

Mouse models using transgenes which generate spontaneous cancers are essential tools to examine the etiology of human diseases. Here, the first Myc-driven spontaneous model is described as a valid HGSOC model. Surprisingly, aspects of uterine serous carcinoma were also observed in this model.

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