Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin

高活性 CAR-T 细胞与间皮素的近膜区域结合，且不会被脱落的间皮素阻断

阅读：9

作者：Xiufen Liu, Masanori Onda, Nathan Watson, Raffit Hassan, Mitchell Ho, Tapan K Bera, Junxia Wei, Anirban Chakraborty, Richard Beers, Qi Zhou, Asif Shajahan, Parastoo Azadi, Jingyu Zhan, Di Xia, Ira Pastan

期刊：

Proceedings of the National Academy of Sciences of the United States of America

影响因子：

时间：

2022

起止号：

2022 May 10;119(19):e2202439119.

doi：

10.1073/pnas.2202439119

种属：

Goat

方法学：

IHC

靶点：

IgG Fc

研究方向：

细胞生物学

细胞类型：

T细胞

Abstract

SignificanceMesothelin (MSLN) is a cell-surface protein that is a popular target for antibody-based therapies. We have identified shed MSLN as a major obstacle to successful antibody therapies and prepared a monoclonal antibody that inhibits shedding and makes very active CAR T cells whose activity is not blocked by shed MSLN and merits further preclinical development.

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