Abstract
AIM: To evaluate effects of high-intensity interval training (HIT) on aerobic exercise capacity, quality of life, and body composition in children with cerebral palsy (CP). METHODS: This was a baseline control trial. Children with CP, Gross Motor Function Classification System (GMFCS) levels I-IV, and age 10-17 years were included. The primary outcome, peak, and submaximum oxygen uptake (VO(2peak), VO(2submax)) were measured at enrolment to the study (T0), after a pretraining period (T1), and after HIT (T2). Secondary outcomes were quality of life assessed with the KINDL questionnaire, and body composition measured using whole body dual-energy X-ray absorptiometry scanning. The exercise was performed on treadmills and consisted of 24 sessions, each with a total of 16 min of exercise at >85% of maximal heart rate. RESULTS: 20 children were included and 6 children dropped out. VO(2peak) increased by 10%, from a median of 37.3 (31.0-40.1) to 41.0 (36.6-48.5) mL/kg/min from T1 to T2 (p<0.01). VO(2submax) did not change; thereby, the percentage oxygen utilisation was reduced. Body composition was unchanged. Parent-reported quality of life improved, whereas quality of life reported by the children did not improve. CONCLUSIONS: Aerobic exercise capacity improved and per cent utilisation of VO(2max) declined after HIT in children with CP. Therefore, HIT can be a time efficient way to improve maximal capacity, and increase energy reserve in this patient group. TRIAL REGISTRATION NUMBER: NCT00965133.