Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas

肿瘤微环境对于原发性胶质母细胞瘤细胞状态的维持至关重要

阅读：4

作者：Allison R Pine #, Stefano M Cirigliano #, James G Nicholson, Yang Hu, Amanda Linkous, Ken Miyaguchi, Lincoln Edwards, Richa Singhania, Theodore H Schwartz, Rohan Ramakrishna, David J Pisapia, Matija Snuderl, Olivier Elemento, Howard A Fine

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2020

起止号：

2020 Jul;10(7):964-979.

doi：

10.1158/2159-8290.CD-20-0057

研究方向：

肿瘤

疾病类型：

胶质瘤

细胞类型：

肿瘤细胞

Significance

It has been unclear how well different patient-derived GBM models are able to recreate the full heterogeneity of primary tumors. Here, we provide a complete transcriptomic characterization of the major model types. We show that the microenvironment is crucial for recapitulating GSC cellular states, highlighting the importance of tumor-host cell interactions.See related commentary by Luo and Weiss, p. 907.This article is highlighted in the In This Issue feature, p. 890.

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