Abstract
BACKGROUND: This randomized controlled trial investigated the role of omega-3 supplementation on C5L2 gene expression in type 2 diabetics. METHODS: Subjects in the omega-3 group received 4 g omega-3 per day and subjects in the placebo group took four capsules of placebo per day for 10 weeks. Gene expression was measured by RT- PCR at the beginning and end of the study. RESULTS: The results of this study show depletion in the omega-3 group, but the mean difference between two groups was not significant. CONCLUSIONS: Understanding the effect of the omega-3 pathway could contribute to targeting treatment of diabetes and its comorbidities.