Aberrant cytokine secretion and zinc uptake in chronic cadmium-exposed lung epithelial cells

慢性镉暴露的肺上皮细胞异常细胞因子分泌和锌吸收

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作者:Yan-Ming Xu, Yang-Min Gao, Dan-Dan Wu, Fei-Yuan Yu, Zhong-Sheng Zang, Lei Yang, Yue Yao, Na-Li Cai, Yuan Zhou, Jen-Fu Chiu, Yick-Pang Ching, Andy T Y Lau

Purpose

Our previous

Results

Here, we explored further and found that the zinc (Zn) importer Zip8 was stably abolished in these cells along with a marked decrease of Cd and Zn accumulation. Moreover, by cell migration assays and cytokine antibody array analysis, we found that Cd-adapted cells exhibit enhanced migratory ability possibly due to elevated secretions of vascular endothelial growth factor and macrophage inflammatory protein-3 alpha (MIP-3α).

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