Abstract
OBJECTIVE: This study was conducted to assess the relationship between aldosterone synthase CYP1A1 MspI gene polymorphism and prostate cancer risk using meta-analysis. METHODS: The search was conducted in PubMed and China Biological Medicine Database disc on October 1, 2015, and eligible reports were recruited and synthesized using meta-analysis method. RESULTS: The eligible reports were recruited into this meta-analysis for the association of CYP1A1 MspI gene polymorphism with prostate cancer risk. In this meta-analysis, CYP1A1 MspI TT genotype was associated with prostate cancer risk, but the association for C allele and CC genotype was not found in this meta-analysis (C allele: odds ratio = 1.11, 95% confidence interval: 0.96-1.29, P = .15; CC: odds ratio = 0.92, 95% confidence interval: 0.75-1.13, P = .43; TT: odds ratio = 0.80, 95% confidence interval: 0.66-0.97, P = .02). CONCLUSION: CYP1A1 MspI TT genotype was associated with prostate cancer susceptibility. However, more studies should be conducted in the future to confirm them.