Radiofluorination of a NHC-PF(5) adduct: toward new probes for (18)F PET imaging

NHC-PF(5)加合物的放射性氟化：用于(18)F PET成像的新型探针

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作者：Vabre,Boris,Chansaenpak,Kantapat,Wang,Mengzhe,Wang,Hui,Li,Zibo,Gabbaï,François P
期刊：Chemical Communications影响因子：4.200
时间：2017起止号：2017 Aug 11;53(62):8657-8659
doi：10.1039/c7cc04402j

Abstract

The radiofluorination of N-heterocyclic carbene (NHC) phosphorus(v) fluoride adducts has been investigated. The results show that the IMe-PF(5) derivative (IMe = 1,3-dimethylimidazol-2-ylidene) undergoes a Lewis acid promoted (18)F-(19)F isotopic exchange. The resulting radiofluorinated probe is remarkably resistant to hydrolysis both in vitro as well as in vivo.

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