Induction of Paracrine Signaling in Metastatic Melanoma Cells by PPARγ Agonist Rosiglitazone Activates Stromal Cells and Enhances Tumor Growth

PPARγ 激动剂罗格列酮诱导转移性黑色素瘤细胞旁分泌信号传导,激活基质细胞并增强肿瘤生长

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作者:Christine Pich, Patrick Meylan, Beatris Mastelic-Gavillet, Thanh Nhan Nguyen, Romain Loyon, Bao Khanh Trang, Hélène Moser, Catherine Moret, Christine Goepfert, Jürg Hafner, Mitchell P Levesque, Pedro Romero, Camilla Jandus, Liliane Michalik

Significance

These findings uncover a novel mechanism by which the thiazolidinedione compound rosiglitazone contributes to tumorigenesis, thus highlighting a potential risk associated with its use in patients with established tumors. Cancer Res; 78(22); 6447-61. ©2018 AACR.

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