Enpp1 deficiency caused chondrocyte apoptosis by inhibiting AMPK signaling pathway

The deficiency of ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1) causes the phenotype similar to knee osteoarthritis (OA). However, the molecular mechanism is poorly understood. Method: The global deletion of Enpp1 (Enpp1-/-) mice was created to analyze the role of Enpp1 in the progress of knee OA. The apoptosis, proliferation and chondrogenic differentiation ability of chondrocytes from wild-type (WT) and Enpp1-/- joints were compared. According to the

Consequently, Enpp1 deficiency plays an essential role in knee OA by regulating AMPK signaling pathway.