Abstract
BACKGROUND: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Management includes surgical resection followed by chemoradiation, and prognosis remains poor. Surgical resection is not possible for some deep-seated or eloquent tumors. Laser interstitial thermal therapy (LITT) has emerged as a new, minimally invasive surgical option for deep-seated GBM. CASE DESCRIPTION: We report a case of newly diagnosed thalamic GBM managed with LITT followed by radiation and chemotherapy. CONCLUSION: The patient remains well at 50-month post-LITT, indicating a potentially unique durability of LITT treatment in GBM.