Development and characterization of an oral microbiome transplant among Australians for the treatment of dental caries and periodontal disease: A study protocol

为治疗龋齿和牙周病而为澳大利亚人开发和表征口腔微生物组移植:一项研究方案

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作者:Sonia Nath, Peter Zilm, Lisa Jamieson, Kostas Kapellas, Nirmal Goswami, Kevin Ketagoda, Laura S Weyrich

Background

Oral microbiome transplantation (OMT) is a novel concept of introducing health-associated oral microbiota into the oral cavity of a diseased patient. The premise is to reverse the state of oral dysbiosis, and restore the ecological balance to maintain a stable homeostasis with the host immune system. This study will assess the effectiveness, feasibility, and safety of OMT using an interdisciplinary approach.

Discussion

If OMTs are found to be successful, it can form a new treatment method for common oral diseases such as dental caries and periodontitis. OMTs may have the potential to modulate the oral microbiota and shift the ecological imbalances to a healthier state.

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