Abstract
Salivary gland tumours are relatively uncommon, and there exists a considerable diagnostic difficulty owing to their diverse histological features in individual lesions and the presence of a number of types and variants, in addition to overlapping histological patterns similar to those observed in different tumour entities. One such group of variations is clear cell tumours of oral cavity which constitute an assorted group of lesions that may be odontogenic or metastatic or of salivary gland origin. The clear cell variant of mucoepidermoid carcinoma is at times misleading to the clinician because of its atypical location and innocent appearance. The pathologist needs to be familiar with the molecular alterations so that there may be a strong potential to implement good treatment. Hereby, we report a rare case of intraosseous clear cell variant of mucoepidermoid carcinoma which histopathologically posed challenges due to its variable presentation, suggesting the need for histochemical stains and molecular work-up for a definitive diagnosis and a better therapeutic and prognostic insight.