Site of origin of the abnormal discharge in the electrocorticogram produced by tubocurarine perfused through the anterior horn of a lateral ventricle

1. In cats anaesthetized with chloralose, perfusion of tubocurarine through the anterior horn of a lateral cerebral ventricle produces a rhythmic discharge of high voltage negative spikes recorded from an electrode inserted into this horn. The discharge spreads to the cerebral cortex where it gives rise to synchronous surface negative deflexions of low voltage. They have previously been described as ;slow waves'.2. The discharge results from an excitatory action of tubocurarine on the anterior limbic area, which is a cortical structure in the medial wall of the anterior horn lying rostral to the septum pellucidum.