Abstract
Milk contains numerous proteins including bioactive molecules that may be important in human nutrition. Thanks to improvements in proteomic methods, hundreds of proteins identified in milk are available through open data from different publications. We gathered these public data to produce an atlas reporting the cow milk proteins. We aggregated data from 20 publications reporting milk proteome and produced an atlas of 4654 unique proteins detected in milk from healthy cows. In this atlas, proteins are categorized according to four milk fractions: skimmed milk, whey, milk fat globule membranes (MFGM) and exosomes; and five lactation stages: colostrum period, early lactation, peak of lactation, mid-lactation and drying-off. These 9 protein lists were compared and annotated by Gene Ontology (GO) terms to identify the pathways they contribute to, the molecular signatures of different milk fractions and lactation stages. This data article compiles the 4654 cow milk proteins. This atlas may be used by researchers on human nutrition interested in milk protein allergy and/or digestibility in humans, and for milk processing industry. The atlas may be useful to i) find molecular signatures of physiological adaptations of dairy cows, ii) facilitate the isolation of proteins of interest, thanks to the knowledge on their presence in milk fractions and their period of secretion during lactation.