Abstract
Our case study highlights the challenges in treating chronic non-bacterial osteitis/osteomyelitis (CNO) of the jaw and supports the current recommendations for diagnosis and treatment, which prioritize newly defined drug treatment strategies. The implementation of regular reevaluations-including magnetic resonance imaging (MRI) if necessary-is essential for the desired treat-to-target strategy. The patient care should be carried out in centers with an interdisciplinary approach and experience in the treatment of CNO.