Cytoskeletal and extracellular matrix proteins as markers for metastatic triple negative breast cancer

细胞骨架和细胞外基质蛋白作为转移性三阴性乳腺癌的标志物

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作者:Mohammed Elimam Ahamed Mohammed, Nuha Mohammed Elhassan

Conclusion

Fibronectin-1 and laminin-1 receptor are promising markers for stage 3 triple negative breast cancer.

Methods

Forty triple negative cancerous breast tissues from patients diagnosed as stage 2A (15), 2B (nine), 3A (10), 3B (four), and 3C (two) were included in this study and were compared with 42 normal breast tissues. Immunohistochemistry

Objective

This study investigated immunohistochemical staining

Results

The percentages of positive staining in cancerous tissues for all of the studied parameters were significantly greater than their percentages in normal tissues, except for vimentin. All cancerous tissues from patients diagnosed as stage 3A, 3B, and 3C were positive for both fibronectin-1 and laminin-1 receptor.

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