X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline

西班牙儿童队列中的 X 染色体遗传数据、数据集描述和分析流程

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作者:Augusto Anguita-Ruiz, Julio Plaza-Diaz, Francisco Javier Ruiz-Ojeda, Azahara I Rupérez, Rosaura Leis, Gloria Bueno, Mercedes Gil-Campos, Rocío Vázquez-Cobela, Ramón Cañete, Luis A Moreno, Ángel Gil, Concepción María Aguilera1

Abstract

X chromosome genetic variation has been proposed as a potential source of missing heritability for many complex diseases, including obesity. Currently, there is a lack of public available genetic datasets incorporating X chromosome genotype data. Although several X chromosome-specific statistics have been developed, there is also a lack of readily available implementations for routine analysis. Here, we aimed: (1) to make public and describe a dataset incorporating phenotype and X chromosome genotype data from a cohort of 915 normal-weight, overweight and obese children, and (2) to deeply describe a whole implementation of the special X chromosome analytic process in genetics. Datasets and pipelines like this are crucial to get familiar with the steps in which X chromosome requires special attention and may raise awareness of the importance of this genomic region.

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