Mutational analysis of the carboxyl terminus of the Moloney murine leukemia virus integration protein

莫洛尼鼠白血病病毒整合蛋白羧基末端的突变分析

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Abstract

The integration protein (IN) is required for retrovirus DNA integration into the host DNA. The function of the C terminus of the Moloney murine leukemia virus IN protein was examined. The terminal 28 amino acids were found to be nonessential. A linker insertion at position 6025, within a 36-amino-acid insertion not found in any other retrovirus, also produced viable virus.

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