Abstract
Using analytical and Monte Carlo modeling, we explored performance of a lightweight wearable helmet-shaped brain positron emission tomography (PET), or BET camera, based on thin-film digital Geiger avalanche photodiode arrays with Lutetium-yttrium oxyorthosilicate (LYSO) or [Formula: see text] scintillators for imaging in vivo human brain function of freely moving and acting subjects. We investigated a spherical cap BET and cylindrical brain PET (CYL) geometries with 250-mm diameter. We also considered a clinical whole-body (WB) LYSO PET/CT scanner. The simulated energy resolutions were 10.8% (LYSO) and 3.3% ([Formula: see text]), and the coincidence window was set at 2 ns. The brain was simulated as a water sphere of uniform F-18 activity with a radius of 100 mm. We found that BET achieved [Formula: see text] better noise equivalent count (NEC) performance relative to the CYL and [Formula: see text] than WB. For 10-mm-thick [Formula: see text] equivalent mass systems, LYSO (7-mm thick) had [Formula: see text] higher NEC than [Formula: see text]. We found that [Formula: see text] scintillator crystals achieved [Formula: see text] full-width-half-maximum spatial resolution without parallax errors. Additionally, our simulations showed that LYSO generally outperformed [Formula: see text] for NEC unless the timing resolution for [Formula: see text] was considerably smaller than that presently used for LYSO, i.e., well below 300 ps.