Effect of Topical Epigallocatechin-Gallate on Lipopolysaccharide-induced Pulpal Inflammation in Rat Models
外用表没食子儿茶素没食子酸酯对大鼠模型中脂多糖诱发牙髓炎症的影响
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作者：Kun Ismiyatin, Soegeng Wahluyo, Djoko Agus Purwanto, Retno Pudji Rahayu, Adioro Soetojo, Indri Safitri Mukono
| 期刊： | Iranian Endodontic Journal | 影响因子： | |
| 时间： | 2018 | 起止号： | 2018 Fall;13(4):528-533. |
| doi： | 10.22037/iej.v13i4.21226 | 研究方向： | 免疫 |
| 信号通路： | Immunology/Inflammation | |
Conclusion
Based on the results of this study, topical application of 75 ppm EGCG hydrogels to the tooth cavities with six hours of pulpal inflammation has the optimal result in reducing the expression of TNF-α and CGRP, but not of MDA.
Results
The T1 and T2 groups showed a significant decrease in TNF-α and CGRP expression compared to the control group, but there was no significant decrease in MDA in either group (P<0.05).
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