Evaluation of Immunogenicity and Clinical Protection of SARS-CoV-2 S1 and N Antigens in Syrian Golden Hamster

SARS-CoV-2 S1 和 N 抗原在叙利亚金仓鼠中的免疫原性和临床保护作用评估

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作者:Zhenye Niu, Xueqi Li, Yang Gao, Lichun Wang, Shengtao Fan, Xingli Xu, Guorun Jiang, Pingfang Cui, Dandan Li, Yun Liao, Li Yu, Heng Zhao, Ying Zhang, Qihan Li

Methods

intradermal and intramuscular administration. Immunized hamsters were challenged with live SARS-CoV-2 14 days after booster immunization. Clinical symptoms were observed daily, and the antibody titer and viral load in each tissue were detected. The

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