Inducamides A-C, chlorinated alkaloids from an RNA polymerase mutant strain of Streptomyces sp

诱导酰胺 AC,链霉菌属 RNA 聚合酶突变株中的氯代生物碱

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Abstract

Inducamides A-C (1-3), three new chlorinated alkaloids featuring an amide skeleton generated by a tryptophan fragment and a 6-methylsalicylic acid unit, were isolated from a chemically induced mutant strain of Streptomyces sp. with the inducamides only being produced in the mutant strain. Their structures, including stereochemistry, were determined by spectroscopic analysis, Marfey's method, and CD spectroscopy.

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