Abstract
Aspergilloma localised solely to the kidneys is very rare and poses diagnostic and therapeutic challenges. We present the case of a 35-year-old male with a background of urolithiasis, type II diabetes and chronic kidney disease, who was found to have isolated renal aspergilloma associated with obstructing uric acid renal tract calculi. After poor progress to clear the fungal infection and remaining stones with ureteroscopy, he was successfully treated by percutaneous nephrolithotomy (PCNL) to surgically remove fungal balls and calculi. Additionally, he was treated with peri-operative oral and systemic antifungals and post-operative irrigation of the renal collecting system with amphotericin.