A recombinant Modified Vaccinia virus Ankara expressing prME of tick-borne encephalitis virus affords mice full protection against TBEV infection

表达蜱传脑炎病毒 prME 的重组改良痘苗病毒安卡拉可为小鼠提供针对 TBEV 感染的全面保护

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作者：Mareike Kubinski, Jana Beicht, Isabel Zdora, Jeannine Biermann, Christina Puff, Thomas Gerlach, Alina Tscherne, Wolfgang Baumgärtner, Albert D M E Osterhaus, Gerd Sutter, Chittappen Kandiyil Prajeeth, Guus F Rimmelzwaan
期刊：Frontiers in Immunology影响因子：5.700
时间：2023起止号：2023 Apr 21:14:1182963.
doi：10.3389/fimmu.2023.1182963研究方向： 免疫、微生物学
疾病类型： 脑炎

Discussion

Our data indicate that MVA-prME holds promise as an improved next-generation vaccine for the prevention of TBE.

Methods

In the present study, we generated and characterized a recombinant Modified Vaccinia virus Ankara (MVA) for the delivery of the pre-membrane (prM) and envelope (E) proteins of TBEV (MVA-prME).

Results

MVA-prME was tested in mice in comparison with a licensed vaccine FSME-IMMUN® and proved to be highly immunogenic and afforded full protection against challenge infection with TBEV.

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