Abstract
Metabolic acidosis is defined as a pathologic process that, when unopposed, increases the concentration of hydrogen ions in the body and reduces the concentration of HCO3. Methanol poisoning is an important cause of metabolic acidosis. Methanol and ethylene glycol poisonings cause scores of fatal intoxications annually, and even relatively small ingestions of these alcohols can produce significant toxicity. Neuroimaging findings are very suggestive and help in the diagnosis even before the measurement of serum methanol (when available at the health service). Rapid recognition and early treatment, including alcohol dehydrogenase inhibition, are crucial. In this sense, some studies question that many intoxications by different chemical agents (in addition to methanol and ethylene glycol) generate a conglomeration of neuroimaging findings that summarily reflect the presence of metabolic acidosis. Therefore, in this article, we discuss the imaging findings of metabolic acidosis, methanol poisoning, and their main differential diagnoses in neuroimaging, directing earlier diagnostic reasoning in order to initiate the most appropriate treatment promptly.