Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis

钙调磷酸酶抑制剂与抗真菌药物在体外对新型隐球菌分离株具有协同作用：与实体器官移植受者隐球菌病预后的相关性

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作者：Kontoyiannis,Dimitrios P,Lewis,Russell E,Alexander,Barbara D,Lortholary,Olivier,Dromer,Françoise,Gupta,Krishan L,John,George T,Del Busto,Ramon,Klintmalm,Goran B,Somani,Jyoti,Lyon,G Marshall,Pursell,Kenneth,Stosor,Valentina,Munoz,Patricia,Limaye,Ajit P,Kalil,Andre C,Pruett,Timothy L,Garcia-Diaz,Julia,Humar,Atul,Houston,Sally,House,Andrew A,Wray,Dannah,Orloff,Susan,Dowdy,Lorraine A,Fisher,Robert A,Heitman,Joseph,Albert,Nathaniel D,Wagener,Marilyn M,Singh,Nina
期刊：Antimicrobial Agents and Chemotherapy影响因子：4.500
时间：2008起止号：2008 Feb;52(2):735-8
doi：10.1128/AAC.00990-07研究方向： 微生物学

Abstract

Synergistic interactions were observed between CIs and antifungal agents against 53 (90%) of 59 Cryptococcus neoformans isolates from solid organ transplant recipients with cryptococcosis and may account for better outcomes in patients with cryptococcosis receiving these immunosuppressive agents.

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