Anti-Hypertensive Activity of Some Selected Unani Formulations: An Evidence-Based Approach for Verification of Traditional Unani Claims Using LC-MS/MS for the Evaluation of Clinically Relevant Blood Parameters in Laboratory Rats

部分尤纳尼配方的抗高血压活性:使用 LC-MS/MS 评估实验室大鼠临床相关血液参数,以验证传统尤纳尼声明的循证方法

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作者:Md Adil Shaharyar, Rudranil Bhowmik, Obaid Afzal, Abdulmalik S A Altamimi, Sami I Alzarea, Waleed Hassan Almalki, Sk Zeeshan Ali, Pallab Mandal, Avishek Mandal, Mohd Ayoob, Imran Kazmi, Sanmoy Karmakar

Background

Systemic arterial hypertension, which is associated with an increased risk of cardiovascular disease(CVD), is the most significant modifiable risk factor for mortality and morbidity worldwide. WHO has recognized Unanipathy as an alternate system of medicine. The

Conclusions

L-NAME KAS, MSR and HJ showed no change in SBP while DMM showed a significant reduction in SBP with decreased plasma nitrite. Probably, DMM may have anti-hypertensive activity mediated through NO inhibition while KGS may involve central sympathomimetic action.

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