DNA Methylation Markers for Detection of Cholangiocarcinoma: Discovery, Validation, and Clinical Testing in Biliary Brushings and Plasma

用于检测胆管癌的 DNA 甲基化标记:胆汁刷检和血浆中的发现、验证和临床检测

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作者:Ju Dong Yang, Hassan Ghoz, Mohammed M Aboelsoud, William R Taylor, Tracy C Yab, Calise K Berger, Xiaoming Cao, Patrick H Foote, Nasra H Giama, Emily G Barr Fritcher, Douglas W Mahoney, Catherine D Moser, Thomas C Smyrk, Benjamin R Kipp, Gregory J Gores, Lewis R Roberts, John B Kisiel

Conclusion

Next-generation DNA sequencing yielded highly discriminant methylation markers for CCA. Confirmation of these findings in independent tissues, cytology brushings, and plasma supports further development of DNA methylation to augment diagnosis of CCA.

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